Monday, July 15

9:00am - 7:00pm Registration Open

1:00pm - 1:15pm Welcome Remarks Keynote Presentation - 1:15pm - 2:00pm 

1:15pm - 2:00pm Tyler Jacks, PhD, Institute for Integrative Cancer Research at MIT, USA TBD

Plenary Session 1: Cancer -  2:15pm - 3:30pm

2:15pm - 2:30pm | Julia Horsfield, University of Otago, New Zealand | Subfunctionalization of cohesin components in zebrafish cell fate determination

2:30pm - 2:45pm | Mohita Tagore, Memorial Sloan Kettering Cancer Center, USA | Reprogramming of the microenvironment by melanoma-derived cytoplasmic transfer

2:45pm - 3:00pm | Alessandro Brombin, The University of Edinburgh, UK | Live-imaging coupled with single-cell RNA sequencing identify zebrafish melanocyte stem cell-derived subpopulations in development

3:00pm - 3:15pm | Kristin Artinger, University of Colorado, USA | Loss of prdm1a accelerates melanoma onset and progression by regulating the melanocyte stem cell factor sox10

3:15pm - 3:30pm | Olivia Piccolo, Dalhousie University, Canada | Nanoparticle-mediated low Z radiotherapy as a potential treatment paradigm for radiosensitive cancers

3:30pm - 3:45pm | Thomas Look, Dana-Farber Cancer Institute, USA | Zebrafish models to optimize melanoma cell death during therapy

3:45pm - 4:15pm | Afternoon Break

Plenary Session 2: Emerging Technology -  4:15pm - 6:00pm

4:15pm - 4:30pm | James Gagnon, The University of Utah, USA | CRISPR lineage tracing in the zebrafish heart and brain

4:30pm - 4:45pm | Robert Bryson-Richardson, Monash University, Australia | Metformin rescues muscle function in preclinical BAG3 myofibrillar myopathy models

4:45pm - 5:00pm | Chloé Baron, Hubrecht Institute, The Netherlands | Cell type purification by single-cell transcriptome-trained sorting

5:00pm - 5:15pm | Marion Rosello, Institut Curie, France | Human genetic cancer mimicry in zebrafish thought somatic base editing

5:15pm - 5:30pm | Chuan Yan, Massachusetts General Hospital, USA | Dynamic single cell imaging of human cancer growth, immunotherapy responses, and stem cell pluripotency following engraftment into immunodeficient zebrafish

5:30pm - 5:45pm | Stephen Ekker, Mayo Clinic, USA | Location, location, location! MMEJ real estate for functional genomics in zebrafish

5:45pm - 6:00pm Flash Talks by:

  • Brijesh Kumar, Greenwood Genetic Center, USA, Repressing to enhance: In vivo chemical screen identifies novel regulators of pancreatic alpha-cell fate and beta-cell regeneration

  • Ankit Sabharwal, Mayo Clinic, USA, A primer genetic toolkit for exploring mitochondrial biology and disease using zebrafish

  • Carolyn Maskin, Weill Cornell Graduate School of Medical Sciences, USA, A total synthetic approach to CRISPR/Cas9 genome editing and homology directed repair

  • Emily Hunt, Duke University, USA, A strategy for cell-specific CRISPR/Cas9 lesions

  • Saara Laukkanen, Tampere University, Finland, Ex vivo screening of drug responses in the zebrafish leukemia model

6:15pm - 7:00pm | Keynote Presentation | Catherine Wu, MD | Dana-Farber Cancer Institute & Harvard Medical School | Personal Neoantigen Cancer Vaccines

6:30pm - 9:00pm | Welcome Reception


Tuesday, July 16th

8:00am - 5:30pm | Registration Open

Plenary Session 3: Development and Disease - 8:30am - 10:15am

8:30am - 8:45am | Nikolay Ninov, Technische Universität Dresden, Germany | One beta-cell to rule them all?

8:45am - 9:00am | Victoria Patterson, Princeton University, USA | Modeling congenital disease in zebrafish: RASopathy-like syndromes arise from novel mutations in MAP4K4

9:00am - 9:15am | Yun-Jin Jiang, Institute of Molecular and Genomic Medicine/National Health Research Institutes, Taiwan | nicastrin deficiency induced Tyrosinase-dependent acquired pigment loss and skin inflammation

9:15am - 9:30am | Pierre Gillotay, Université Libre de Bruxelles, Belgium | A closer look upon thyroid functional maturation: a nrf2a story

9:30am - 9:45am | Daniel Grimes, University of Oregon, USA | CRISPR screens in zebrafish identify regulators of left-right asymmetry

9:45am - 10:00am | Andrea Pauli, Research Institute of Molecular Pathology, Austria | Bouncer mediates species-specificity of fertilization

10:00am - 10:15am Flash Talks by:

  • Alberto Dinarello, University of Padua, Italy, Stat3 is necessary for the induction of Hif1 alfa transcriptional activity

  • Diane Sepich, Washington University School of Medicine, Looking for adolescent idiopathic scoliosis mechanisms in zebrafish

  • Alessandra Welker, Massachusetts General Hospital, USA, PlexinA1 is a driver of metastasis and growth in rhabdomyosarcoma

  • Jana Travnickova, University of Edinburgh, UK, MITF-low zebrafish melanomas reveal transcriptional signature subdivisions and cellular subpopulations of residual disease in vivo

  • Gerissa Fowler, Memorial University of Newfoundland, Canada, Understanding the role of GDP-fucose synthesis in blood vessel stability and circular swimming behavior using zebrafish models

10:15am - 10:45am | Morning Break

Concurrent Session 4A: Cancer II - 10:45am - 12:30pm

10:45am - 11:00am | Alec Gramann, University of Massachusetts Medical School, USA | Reiterated BMP signaling in melanocyte development and melanoma

11:00am - 11:15am | Ali Raja, Boston Children's Hospital, USA | A zebrafish functional screen reveals novel driver oncogenes in liposarcoma

11:15am - 11:30am | Renuka Raman, Weill Cornell Medicine, USA | The identification of SHP2 as a therapeutic target in RET rearranged thyroid cancers

11:30am - 11:45am | Nathaniel Campbell, Memorial Sloan Kettering Cancer Center, USA | Heterogeneous cell clusters promote melanoma metastasis via cell-cell cooperation

11:45am - 12:00pm | Megan Insco, Dana-Farber, Boston Children's Hospital, USA | CDK13 mutations drive melanoma via accumulation of prematurely terminated transcripts

12:00pm - 12:15pm | Heather Shive, NC State University College of Veterinary Medicine, USA | Genotypic and phenotypic variables affect meiotic cell cycle progression, tumor ploidy, and cancer-associated mortality in a brca2-mutant zebrafish model

12:15pm - 12:30pm | Hui Feng, Boston University, USA | S1P1 phosphorylation promotes triple-negative breast cancer invasiveness

Concurrent Session 4B: Gastrointestinal - 10:45am - 12:30pm

10:45am - 11:00am | Wenbiao Chen, Vanderbilt University School of Medicine, USA | Metabolic stress induces Ripk3- and macrophage-dependent beta-cell loss in zebrafish

11:00am - 11:15am | Arkadi Shwartz, Brigham and Women's Hospital, USA | Beyond metchnikoff’s phagocytosis theory: How macrophages regulate TGF-beta signaling during zebrafish liver development

11:15am - 11:30am | Duc Dong, Sanford Burnham Prebys Medical Discovery Institute, USA | Reversing Alagille Syndrome pathologies:  a novel liver regenerative progenitor source and a promising lead compound

11:30am - 11:45am | Lihua Ye, Duke University, USA | Enteroendocrine cells sense gut bacteria and activate a gut-brain pathway

11:45am - 12:00pm | Seok-Hyung Kim, Medical University of South Carolina, USA | Palmitic acid-enriched diet induces hepatic steatosis and injury in adult zebrafish

12:00pm - 12:15pm | David James, University of Miami, USA | Intestinal dysmotility and reduced serotonin-positive enteroendocrine cells in a shank3 loss-of-function model of Autism Spectrum Disorder

12:15pm - 12:30pm | Herman Spaink, Leiden University, The Netherlands | A high through-put screen for antidiabetic compounds in zebrafish embryos

12:30pm - 2:30pm | Lunch and Poster Session I

Mentoring/ Education Sessions - 2:30pm - 3:30pm

3:30pm - 4:00pm | Afternoon Break

Concurrent Session 5A: Hematology I - 4:00pm - 5:45pm

4:00pm - 4:15pm | Clair Kelley, St. Jude Children's Research Hospital, USA | Contribution of sclerotome to the embryonic hematopoietic stem cell niche and vascular smooth muscle

4:15pm - 4:30pm | Wade Sugden, Boston Children's Hospital, USA | YAP regulates hematopoietic stem cell formation in response to the biophysical forces of blood flow

4:30pm - 4:45pm | Jessica Burroughs-Garcia, University of Oklahoma Health Sciences Center, USA | Analysis of leukemia stem cells in a MYC-driven ALL zebrafish model

4:45pm - 5:00pm | Pietro Cacialli, University of Geneva, Switzerland | The endothelial niche detoxifies HSCs from ROS in the caudal hematopoietic tissue.

5:00pm - 5:15pm | Giuliano Ferrero, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Belgium | The macrophage-expressed gene (mpeg) 1.1 identifies a subpopulation of B cells in the adult zebrafish

5:15pm - 5:30pm | Usua Oyarbide, Cleveland Clinic, USA | A zebrafish model for Shwachman-Diamond syndrome reveals dynamic p53-dependent changes and suggests a p53-independent role in developmental abnormalities

5:30pm - 5:45pm | Emma de Pater, Erasmus University Medical Cente, The Netherlands | A zebrafish model for Gata2 haploinsufficiency mediated myeloid malignancy

Concurrent Session 5B: Cardiac and Musculoskeletal - 4:00pm - 5:45pm

4:00pm - 4:15pm | Christoph Winkler, National University of Singapore, Singapore | Chemokine signaling is a driver of osteoclast recruitment in a medaka osteoporosis model

4:15pm - 4:30pm | Sahar Tavakoli, Harvard University, USA | A cross-species biomolecule screen uncovers chemical inducers of skeletal muscle engraftment

4:30pm - 4:45pm | Jenica Van Gennip, Unoiversity of Toronto, Canada | Focal neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis

4:45pm - 5:00pm | Matthew Harris, Harvard Medical School, Boston Children's Hospital, USA | On building and rebuilding the skeleton

5:00pm - 5:15pm | Meredith Wilson, Carnegie Institution for Science, USA | A new zebrafish allele of microsomal triglyceride transfer protein suggests that selectively inhibiting triglyceride transfer would be effective to treat dyslipidemia

5:15pm - 5:30pm | Matthew Stoyek, Dalhousie University, Canada | Optogenetic modulation of central and intracardiac neural pathways controlling heart rhythm in zebrafish in development, ageing, and disease

5:30pm - 5:45pm | Geoff Burns, Boston Children's Hospital, USA | Latent TGF? binding proteins 1 and 3 function redundantly to protect zebrafish from aortic root aneurysm

RIG Workshops - 6:00pm - 7:00pm

7:00pm - 11:00pm | Grad Student/ Post Doc Night Out


Wednesday, July 17th

8:00am - 5:30pm | Registration Open

Plenary Session 6: Infection and immunity - 8:30am - 10:15am

8:30am - 8:45am | Phil Elks, University of Sheffield, UK | (ZDM)2: Hif-1alpha modulates neutrophil migration to inflammation and infection sites in a dual-model

8:45am - 9:00am | Jeffrey Yoder, NC State University, USA | Understanding the molecular diversification of self recognition through ray-finned fish innate immune receptor families

9:00am - 9:15am | Qing Deng, Purdue University, USA | Phenotypic microRNA screen reveals miR-199 and CDK2 as novel regulators of neutrophil migration and systemic inflammation

9:15am - 9:30am | Robert Wheeler, University of Maine, USA | Intravital imaging of fungal-innate immune interactions

9:30am - 9:45am | Pramuk Keerthisinghe, The University of Auckland, New Zealand | Helping immunity run like clockwork: the core clock gene per2 contributes to neutrophil bactericidal activity in a cell-autonomous fashion

9:45am - 10:00am | Lali Ramakrishnan, University of Cambridge, UK |

10:00am - 10:15am | Flash Talks by:

  • Madina Wane, Imperial College London, UK, Developing a zebrafish gill model of respiratory mucosal immune responses

  • Anna Cordeiro, Dalhousie University, Canada, A zebrafish JAK1-A634D gain-of-function model provides new insights into the pathogenesis of familial hypereosinophilia

  • Payton Laurie, California State University, Chico, USA, ccl44: a chemokine critical for normal hematopoiesis

  • Ellie Meader, Boston Children's Hospital, USA, Foxo3 directed mitophagy plays a key role in protecting proliferating embryonic hematopoietic stem cells from oxidative stress

  • Michael Phelps, University of Washington, USA, Characterizing novel tumor suppressors in rhabdomyosarcoma

10:15am - 10:45am | Morning Break

Plenary Session 7: Hematology II - 10:45am - 12:30pm

10:45am - 11:00am | Jerone den Hertog, Hubrecht Institute, The Netherlands | Zebrafish with Noonan Syndrome develop myeloproliferative disease

11:00am - 11:15am | Serine Avagyan, Dana-Farber, Boston Children's Hospital, USA | Color barcoding and mosaic mutagenesis confirms mutant ASXL1 as a potent initiator of clonal hematopoiesis

11:15am - 11:30am | Teresa Bowman, Albert Einstein College of Medicine, USA | Stat3 inhibition is a synthetic lethal vulnerability for Sf3b1-mutated hematopoietic cells

11:30am - 11:45am | Rui Monteiro, Institute of Cancer and Genomic Sciences, University of Birmingham, UK | Deletion of a conserved gata2a enhancer induces MonoMAC syndrome in zebrafish and reveals a requirement for gata2a in embryonic and adult haematopoiesis

11:45am - 12:00pm | Jenna Frame, Boston Children's Hospital, USA | Inflammasome-mediated expansion of the hematopoietic system in the vertebrate embryo

12:00pm - 12:15pm | Petr Bartunek, Institute of Molecular Genetics, Czech Republic | Reprogramming of hematopoietic cell fate by cytokine switch

12:15pm - 12:30pm | Zilong Wen, The Hong Kong University Science and Technology, Hong Kong | An Ectoderm-Derived Myeloid-Like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis

12:30pm - 2:30pm | Lunch and Poster Session II

Plenary Session 8: Neurobiology - 2:30pm - 4:15pm

2:30pm - 2:45pm | Kristen Kwan, University of Utah, USA | Hedgehog signaling and the etiology of uveal coloboma

2:45pm - 3:00pm | Sevinç Gücüm, Centre for Organismal Studies, Germany | Mimicking congenital disorders of glycosylation in medaka unravels the role of N-glycosylation in central nervous system development

3:00pm - 3:15pm | Angie Serrano, University of Utah, USA | Notch signaling hyperactivation is the leading cause of microcephaly in Kabuki Syndrome zebrafish

3:15pm - 3:30pm | Bradley Smith, Kings College Lonon, UK | Elucidating the role of Annexin A11 in ALS using over-expression and CRISPR zebrafish models

3:30pm - 3:45pm | Danielle Tomasello, Whitehead Institute, USA | FAM57B ceramide synthase, a hub gene within 16p11.2 deletion syndrome, maintains physiological lipid membrane composition

3:45pm - 4:00pm | Kathryn Adamson, University of Sheffield, UK | Developing zebrafish models to investigate the role of TCP1 in a rare neurological disease

4:00pm - 4:15pm | Tripti Gupta, National Institutes of Health, USA | Whole brain morphometric analysis to identify convergent functions of autism-risk genes

4:15pm - 4:30pm | Flash Talks by:

  • Natasha O'Brown, Harvard Medical School, USA, Suppression of transcytosis is a conserved mechanism of functional blood-brain barrier formation during zebrafish development

  • Roberto Rodriguez, University of Puerto Rico, Puerto Rico, The zebrafish atf5a-KO, atf5b-KO and atf5a/b-DO to model neurodegenerative disorders

  • Jeongwon Lee, Jeju National University, South Korea, Exposure to Dithiopyr induces an abnormal swimming patterns in Zebrafish

  • Maximilian Breuer, INRS - Institut Armand-Frappier, Canada, A novel function for the serotonin receptor HTR2B in CHARGE Syndrome

  • Howard Sirotkin, Stony Brook University, USA, Modeling NMDAR-associated neurological disorders

Women in Science - 4:30pm - 5:30pm

7:00pm - 11:00pm | Conference Dinner  - Boston Aquarium


Thursday, July 18th



8:00am - 2:00pm | Registration Open

Pleanary Session 9: Stem Cells and Regeneration - 8:30am - 10:15am

8:30am - 8:45am | Catherina Becker, University of Edinburg, UK | Successful regeneration in larval zebrafish

8:45am - 9:00am | Isaac Oderberg, Brigham and Women's Hospital, USA | Single-cell analysis identifies a population of liver progenitor cells during regeneration

9:00am - 9:15am | Han Wang, Soochow University, China | The circadian clock promotes spermatogonial differentiation and fertilization through retinoic acid signaling

9:15am - 9:30am | Makoto Kobayashi, U Tsukauba, Japan | Regulation and function of the Keap1-Nrf2 pathway in zebrafish stress response

9:30am - 9:45am | Mayssa Mokalled, Washington University School of Medicine, USA | Mechanisms of glial bridging during spinal cord regeneration

9:45am - 10:00am | Xubo Niu, Massachusetts General Hospital, USA | Identification of tendon-promoting drugs for orthopaedic regenerative medicine

10:00am - 10:15am | Jinrong Peng, Zhejiang University, China | Zebrafish hhex null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1

10:15am - 10:30am | Flash Talks by:

  • Anja Arner, Dr. von Hauner Children’s Hospital, Ludwig Maximilians University, Germany, Analysis of leukemia-niche interactions to predict clinical outcome in a patient-derived xenograft model

  • Patrick Sips, Ghent University, Belgium, Generating a new zebrafish model for Marfan syndrome

  • Rebecca Cunningham, University of Washington, USA, Identification of melanoma initiation-associated sox10 enhancers

  • Rodrigo Moreno-Campos, Greehey Children's Cancer Research Institute, USA

  • Shahad Albadri, Curie Institute, France, Redox signaling via lipid peroxidation regulates retinal progenitor cell differentiation

10:30am - 11:00am | Morning Break

Excellence in Research Awardees

11:00am - 11:10am | Award Summary and announcement of speakers | Graham Lieschke, ZDMS President, Marina Mione

11:10am - 11:35am | Craig Ceol, University of Massachusetts Medical School, USA

11:35am - 12:00pm | Eirini Trompouki, Max Planck Institute of Immunobiology and Epigenetics, Germany | Interplay between retroelements and Mda5 regulates developmental and regenerative hematopoiesis

12:00pm - 12:30pm | Community Meeting

12:30pm - 2:30pm | Lunch and Poster Session III

Plenary Session 10 - 2:30pm - 4:00pm

2:30pm - 2:45pm | Joan Heath, Walter and Eliza Hall Inst, Australia | Tapping into zebrafish digestive organ development to identify new targets for cancer therapy

2:45pm - 3:00pm | Emily Rosowski, Clemson University, USA | Analyzing the activity of anti-fungal drugs in vivo in larval zebrafish infected with A. fumigatus

3:00pm - 3:15pm | Anne Clatworthy, Broad Institute, USA | Chemical screening for anti-infectives in zebrafish reveals a novel role for iGluRs in innate immunity

3:15pm - 3:30pm | Ellen Hoffman, Yale University, USA | High-throughput behavioral characterization of zebrafish models of autism risk genes

3:30pm - 3:45pm | Jaime Wertman, Dalhousie University, Canada | Developing a model to screen for compounds that protect against cisplatin-induced toxicities

3:45pm - 4:00pm | Leonard Zon, Boston Children's Hospital, USA 

4:00pm - 4:30pm | Closing Remarks

4:30pm - 7:00pm | Board Meeting